First Direct Evidence That ADHD Is a Genetic
Disorder: Children With ADHD More Likely to Have Missing or Duplicated Segments of DNANew research provides the first direct evidence that attention-deficit/hyperactivity disorder (ADHD) is a genetic condition. Scientists at Cardiff University found that children with ADHD were more likely to have small segments of their DNA duplicated or missing than other children.
The study also found significant overlap between

In a new study, children with ADHD were more likely to have small segments of their DNA duplicated or missing than
other children. (Credit: iStockphoto/Zmeel

these segments, known as copy number variants (CNVs), and genetic
variants implicated in autism and schizophrenia, proving strong evidence
that ADHD is a neurodevelopmental disorder -- in other words, that the
brains of children with the disorder differ from those of other children.
The research, published in the journal

The Lancet, was largely funded by the Wellcome Trust, with additional support from Action Medical Research, the Medical Research
Council and the European Union.

"We hope that these findings will help overcome the stigma associated
with ADHD," says Professor Anita Thapar. "Too often, people dismiss ADHD as being down to bad parenting or poor diet. As a clinician, it was clear to me that this was unlikely to be the case. Now we can say with
confidence that ADHD is a genetic disease and that the brains of children
with this condition develop differently to those of other children."

ADHD is one of the most common mental health disorders in childhood,
affecting around one in 50 children in the UK. Children with ADHD are
excessively restless, impulsive and distractible, and experience
difficulties at home and in school. Although no cure exists for the
condition, symptoms can be reduced by a combination of medication and
behavioural therapy.

The condition is highly heritable -- children with ADHD are
statistically more likely to also have a parent with the condition and a
child with an identical twin with ADHD has a three in four chance of also
having the condition. Even so, until now there has been no direct evidence
that the condition is genetic and there has been much controversy
surrounding its causes, which some people have put down to poor parenting skills or a sugar-rich diet.

The team at Cardiff University analysed the genomes of 366 children,
all of whom had been given a clinical diagnosis of ADHD, against over
1,000 control samples in search of variations in their genetic make-up
that were more common in children with the condition.

"Children with ADHD have a significantly higher rate of missing or duplicated DNA segments compared to other children and we have seen a clear genetic link between these segments and other brain disorders,"
explains Dr Nigel Williams. "These findings give us tantalising clues to
the changes that can lead to ADHD."

The researchers found that rare CNVs were almost twice as common in
children with ADHD compared to the control sample -- and even higher for children with learning difficulties. CNVs are particularly common in
disorders of the brain.

There was also significant overlap between CNVs identified in children
with ADHD and regions of the genome which are known to influence
susceptibility to autism and schizophrenia. Whilst these disorders are
currently thought to be entirely separate, there is some overlap between
ADHD and autism in terms of symptoms and learning difficulties. This new research suggests there may be a shared biological basis to the two

The most significant overlap was found at a particular region on
chromosome 16 which has been previously implicated in schizophrenia and other major psychiatric disorders and spans a number of genes including one known to play a role in the development of the brain .

"ADHD is not caused by a single genetic change, but is likely caused by
a number of genetic changes, including CNVs, interacting with a child's
environment," explains Dr Kate Langley. "Screening children for the CNVs that we have identified will not help diagnose their condition. We already have very rigorous clinical assessments to do just that."

Dr John Williams, Head of Neuroscience and Mental Health at the
Wellcome Trust, which has supported Professor Thapar's work for ten years, says: "These findings are testament to the perseverance of Professor Thapar and colleagues to prove the often unfashionable theory that ADHD is a brain disorder with genetic links. Using leading-edge technology, they have begun to shed light on the causes of what is a complex and often distressing disorder for both the children and their families."

Editor's Note: This article is not intended to provide medical
advice, diagnosis or treatment. source :

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